ChloroquineV1, France, Analysis, bibRecord, 000272

Antimalarial activity of simalikalactone E, a new quassinoid from quassia amara L (simaroubaceae)

Identifieur interne : 000272 ( France/Analysis ); précédent : 000271; suivant : 000273

Antimalarial activity of simalikalactone E, a new quassinoid from quassia amara L (simaroubaceae)

Auteurs : N. Cachet [France] ; Franciane Hoakwie [France] ; Stéphanie Bertani [France] ; Geneviève Bourdy [France] ; Eric Deharo [France] ; Didier Stien ; Emeline Houel ; Heinz Gornitzka [France] ; Judith Fillaux [France] ; S. Chevalley [France] ; Alexis Valentin [France] ; V. Jullian [France]

Source :

Antimicrobial Agents and Chemotherapy [ 0066-4804 ] ; 2009.

RBID : Hal:hal-01032126

English descriptors

mix :
- .

Abstract

We report the isolation and identification of a new quassinoid named simalikalactone E (SkE), extracted from a widely used Amazonian antimalarial remedy made out of Quassia amara L. (Simaroubaceae) leaves. This new molecule inhibited the growth of Plasmodium falciparum cultured in vitro by 50%, in the concentration range from 24 to 68 nM, independently of the strain sensitivity to chloroquine. We also showed that this compound was able to decrease gametocytemia with a 50% inhibitory concentration sevenfold lower than that of primaquine. SkE was found to be less toxic than simalikalactone D (SkD), another antimalarial quassinoid from Q. amara, and its cytotoxicity on mammalian cells was dependent on the cell line, displaying a good selectivity index when tested on nontumorogenic cells. In vivo, SkE inhibited murine malaria growth of Plasmodium vinckei petteri by 50% at 1 and 0.5 mg/kg of body weight/day, by the oral or intraperitoneal routes, respectively. The contribution of quassinoids as a source of antimalarial molecules needs therefore to be reconsidered.

Url:

https://hal.archives-ouvertes.fr/hal-01032126

DOI: 10.1128/AAC.00951-09

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000019
to stream Hal, to step Curation: 000019
to stream Hal, to step Checkpoint: 000203
to stream Main, to step Merge: 001779
to stream Main, to step Curation: 001775
to stream Main, to step Exploration: 001775
to stream France, to step Extraction: 000272

Links to Exploration step

Hal:hal-01032126

Le document en format XML

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          <orgName>Institut de Chimie de Toulouse</orgName>
          <orgName type="acronym">ICT-FR 2599</orgName>
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<country>France</country>
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<author><name sortKey="Fillaux, Judith" sort="Fillaux, Judith" uniqKey="Fillaux J" first="Judith" last="Fillaux">Judith Fillaux</name>
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          <desc>            <address>              <addrLine>Toulouse</addrLine>
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          <desc>            <address>              <country key="FR"></country>
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        </org>
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</hal:affiliation>
<country>France</country>
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<author><name sortKey="Chevalley, S" sort="Chevalley, S" uniqKey="Chevalley S" first="S." last="Chevalley">S. Chevalley</name>
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          <desc>            <address>              <addrLine>Université Paul SabatierFaculté de pharmacie35 Chemin des Maraîchers31062 Toulouse Cedex France </addrLine>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Valentin, Alexis" sort="Valentin, Alexis" uniqKey="Valentin A" first="Alexis" last="Valentin">Alexis Valentin</name>
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          <desc>            <address>              <addrLine>Université Paul SabatierFaculté de pharmacie35 Chemin des Maraîchers31062 Toulouse Cedex France </addrLine>
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          <idno type="ISNI">0000000121617331</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <desc>            <address>              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"></country>
            </address>
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          <desc>            <address>              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
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</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Jullian, V" sort="Jullian, V" uniqKey="Jullian V" first="V." last="Jullian">V. Jullian</name>
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          <desc>            <address>              <addrLine>Université Paul SabatierFaculté de pharmacie35 Chemin des Maraîchers31062 Toulouse Cedex France </addrLine>
              <country key="FR"></country>
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          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <desc>            <address>              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
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          <desc>            <address>              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
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</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1128/AAC.00951-09</idno>
<series><title level="j">Antimicrobial Agents and Chemotherapy</title>
<idno type="ISSN">0066-4804</idno>
<imprint><date type="datePub">2009</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">              <p>We report the isolation and identification of a new quassinoid named simalikalactone E (SkE), extracted from a widely used Amazonian antimalarial remedy made out of Quassia amara L. (Simaroubaceae) leaves. This new molecule inhibited the growth of Plasmodium falciparum cultured in vitro by 50%, in the concentration range from 24 to 68 nM, independently of the strain sensitivity to chloroquine. We also showed that this compound was able to decrease gametocytemia with a 50% inhibitory concentration sevenfold lower than that of primaquine. SkE was found to be less toxic than simalikalactone D (SkD), another antimalarial quassinoid from Q. amara, and its cytotoxicity on mammalian cells was dependent on the cell line, displaying a good selectivity index when tested on nontumorogenic cells. In vivo, SkE inhibited murine malaria growth of Plasmodium vinckei petteri by 50% at 1 and 0.5 mg/kg of body weight/day, by the oral or intraperitoneal routes, respectively. The contribution of quassinoids as a source of antimalarial molecules needs therefore to be reconsidered.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><noCountry><name sortKey="Houel, Emeline" sort="Houel, Emeline" uniqKey="Houel E" first="Emeline" last="Houel">Emeline Houel</name>
<name sortKey="Stien, Didier" sort="Stien, Didier" uniqKey="Stien D" first="Didier" last="Stien">Didier Stien</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Cachet, N" sort="Cachet, N" uniqKey="Cachet N" first="N." last="Cachet">N. Cachet</name>
</noRegion>
<name sortKey="Bertani, Stephanie" sort="Bertani, Stephanie" uniqKey="Bertani S" first="Stéphanie" last="Bertani">Stéphanie Bertani</name>
<name sortKey="Bourdy, Genevieve" sort="Bourdy, Genevieve" uniqKey="Bourdy G" first="Geneviève" last="Bourdy">Geneviève Bourdy</name>
<name sortKey="Chevalley, S" sort="Chevalley, S" uniqKey="Chevalley S" first="S." last="Chevalley">S. Chevalley</name>
<name sortKey="Deharo, Eric" sort="Deharo, Eric" uniqKey="Deharo E" first="Eric" last="Deharo">Eric Deharo</name>
<name sortKey="Fillaux, Judith" sort="Fillaux, Judith" uniqKey="Fillaux J" first="Judith" last="Fillaux">Judith Fillaux</name>
<name sortKey="Gornitzka, Heinz" sort="Gornitzka, Heinz" uniqKey="Gornitzka H" first="Heinz" last="Gornitzka">Heinz Gornitzka</name>
<name sortKey="Hoakwie, Franciane" sort="Hoakwie, Franciane" uniqKey="Hoakwie F" first="Franciane" last="Hoakwie">Franciane Hoakwie</name>
<name sortKey="Jullian, V" sort="Jullian, V" uniqKey="Jullian V" first="V." last="Jullian">V. Jullian</name>
<name sortKey="Valentin, Alexis" sort="Valentin, Alexis" uniqKey="Valentin A" first="Alexis" last="Valentin">Alexis Valentin</name>
</country>
</tree>
</affiliations>
</record>

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Antimalarial activity of simalikalactone E, a new quassinoid from quassia amara L (simaroubaceae)

Antimalarial activity of simalikalactone E, a new quassinoid from quassia amara L (simaroubaceae)

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